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Washington (CNN) - President Barack Obama said Wednesday that the "misconduct" detailed in a report about the Internal Revenue Service's handling of requests from conservative groups is "inexcusable."
"Americans have a right to be angry about it, and I am angry about it," he said.
In the wake of the uproar, Treasury Secretary Jack Lew requested - and has accepted - the resignation of the acting commissioner of the Internal Revenue Service, according to Obama.
The president also said his administration will work to enact "new safeguards to make sure that this kind of behavior cannot happen again."
By Jake Tapper, CNN Chief Washington Correspondent
(CNN)– The White House released more than 100 pages of e-mails on Wednesday in a bid to quell critics who say President Barack Obama and his aides played politics with national security following the deadly attack on the U.S. diplomatic compound in Benghazi, Libya.
The exchanges detailing discussions between top Obama administration officials from multiple agencies suggest the CIA took the lead in developing talking points to describe the attack last September 11 that killed Ambassador Christopher Stevens and three other Americans.
Brian Todd reports on claims by Russia's counterintelligence agency to have taken down a CIA spy.
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CNN's Dana Bash investigates the IRS targeting of conservative political groups and their failure to report wrongdoing.
RELATED STORY: Obama says some IRS employees 'failed,' orders accountability
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Man who charged elephant spared life, but not job. CNN's Jeanne Moos reports.