Washington (CNN) – President Barack Obama said Wednesday that the "misconduct" detailed in a report about the Internal Revenue Service's handling of requests from conservative groups is "inexcusable."
"Americans have a right to be angry about it, and I am angry about it," he said.
In the wake of the uproar, Treasury Secretary Jack Lew requested - and has accepted - the resignation of the acting commissioner of the Internal Revenue Service, according to Obama.
The president also said his administration will work to enact "new safeguards to make sure that this kind of behavior cannot happen again."
Rep. Issa also discusses the alleged IRS political targeting of conservative groups, telling CNN's Wolf Blitzer that "it can't happen again."
On the news from the Associated Press that the Justice Department subpoenaed their phone records, Issa calls it disturbing. "They had an obligation to look for every other way to get it before they in fact intruded on the freedom of the press," he says.
President Obama reiterated that investigators do not yet know who is behind the explosions in Boston.
President Obama stirs up a hornets' nest with a comment about California's attorney general. CNN's Rene Marsh explains.
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Brian Todd reports on a new book that says the Obama foreign policy team was wracked with political rivalries.
Jessica Yellin looks at the Barack Obama we see in office now and how his public persona has changed since re-election.
The Obama girls are growing up before our eyes. CNN's Lisa Sylvester reports on how they can act both poised and normal.